Global Snapshot of Protein Interaction Network in Yeast
Reference: Chin CS, Samanta MP. "Global snapshot of a protein interaction network-a percolation based approach." Bioinformatics. 2003 19(18):2413-9. Download.
In this work, we study large-scale protein interaction network of yeast from DIP database utilizing a stochastic method based upon percolation of random graphs. In order to find the global features of connectivities in the network, we introduce numerical measures that quantify (1) how strongly a protein ties with the other parts of the network and (2) how significantly an interaction contributes to the integrity of the network.
Our study shows that the distribusion of inviable proteins is distinct from the background in terms of global connectivities. This observation highlights a fundamental difference betweem the inviable and the viable proteins in the network.
Furthermore, we find that the interaction data obtained from different experimental method such as immunoprecipitation and two-hybrid technique possess different characteristics.
To download our paper on this topic, please click here.
MORE INFORMATION
Additional informations on our calculations are available -
(a) v_i for the proteins -html, text.
(b) beta for all the edges (interactions) html,
text.
Definitions of 'v_i' and 'beta' are given in our paper.